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The bioavailability of 25(OH)VD 3 in the blood in response to dietary VD intake varies significantly among individual subjects and is dependent on the status of the VD metabolism genes 14,15,16,17
Hofstee et al., 2017)
Common gastrointestinal side effects: The most frequently reported adverse effects are gastrointestinal in nature, occurring in up to 40-80% of patients with higher doses, particularly during dose escalation: [13] [14] Nausea (most common, typically improves after 4-8 weeks) Vomiting Diarrhoea or constipation Abdominal discomfort or bloating Reduced appetite These effects can be minimised by starting with low doses and gradually titrating upwards according to manufacturer guidance
Same routine for months or years
Even travel is affected, with activity-centered vacations replacing food-centric getaways
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